Issue 48, 2016
From the journal:

Chemical Communications

Design of a novel microtubule targeted peptide vesicle for delivering different anticancer drugs†

Anindyasundar Adak,‡a   Saswat Mohapatra,‡ab   Prasenjit Mondal,ab   Batakrishna Janaa  and  Surajit Ghosh*ab  

* Corresponding authors

a Organic & Medicinal Chemistry Division, CSIR-Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Jadavpur, Kolkata-700032, West Bengal, India
E-mail: sghosh@iicb.res.in
Fax: +91-33-2473-5197/0284
Tel: +91-33-2499-5872

b Academy of Scientific and Innovative Research (AcSIR), CSIR-Indian Institute of Chemical Biology Campus, 4 Raja S. C. Mullick Road, Kolkata 700 032, India

Abstract

A microtubule targeted peptide-based delivery vehicle has been designed using two oppositely charged peptides, which targets tubulin/microtubules, delivers both hydrophilic and hydrophobic drugs into their target site through lysosome at acidic pH. Drug loaded vesicles show a significant anticancer effect compared to control drugs in a 2D monolayer and a 3D spheroid cell.

Graphical abstract: Design of a novel microtubule targeted peptide vesicle for delivering different anticancer drugs

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Article information

DOI
https://doi.org/10.1039/C6CC01769J
Article type
Communication
Submitted
27 Feb 2016
Accepted
22 Apr 2016
First published
26 Apr 2016

Chem. Commun., 2016,52, 7549-7552

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Design of a novel microtubule targeted peptide vesicle for delivering different anticancer drugs

A. Adak, S. Mohapatra, P. Mondal, B. Jana and S. Ghosh, Chem. Commun., 2016, 52, 7549 DOI: 10.1039/C6CC01769J

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