Issue 31, 2016
From the journal:

RSC Advances

Self-assembly, doxorubicin-loading and antibacterial activity of well-defined ABA-type amphiphilic poly(N-vinylpyrrolidone)-b-poly(d,l-lactide)-b-poly(N-vinyl pyrrolidone) triblock copolymers

K. Ramesh,ab   Ravi Kumar Gundampati,†c   Shikha Singh,a   Kheyanath Mitra,a   Ankita Shukla,c   Medicherla V. Jagannadham,c   Dipankar Chattopadhyay,d   Nira Misrab  and  Biswajit Ray*a  

* Corresponding authors

a Department of Chemistry, Faculty of Science, Banaras Hindu University, Varanasi – 221005, India
E-mail: biswajitray2003@yahoo.co.in

b School of Biomedical Engineering, Indian Institute of Technology (Banaras Hindu University), Varanasi-221005, India

c Molecular Biology Unit, Institute of Medical Science, Banaras Hindu University, Varanasi – 221005, India

d Department of Polymer Science and Technology, University of Calcutta, 92, A. P. C. Road, Kolkata-700 009, India

Abstract

A series of ABA type well-defined amphiphilic poly(N-vinylpyrrolidone) (PNVP)-b-poly(D,L-lactide)-b-PNVP triblock copolymers have been synthesized via the combination of ring opening polymerization and xanthate-mediated reversible addition–fragmentation chain transfer polymerization, and analyzed by 1H NMR spectroscopy and gel permeation chromatography. Aggregation properties of these amphiphilic triblock copolymers have been revealed by fluorescence spectroscopy, transmission electron microscopy and dynamic light scattering, and supported by 1H NMR spectroscopy. Doxorubicin (DOX) has successfully been loaded into the block copolymer micelles with a loading efficiency of 37.5%. DOX-loaded PNVP51-b-PDLLA48-b-PNVP51 block copolymer showed sustained release within 36 h. Antibacterial properties of DOX-loaded micelles have been found to be significantly effective with respect to free DOX in terms of minimum inhibitory concentration, disk diffusion assay, growth curve, bacterial reduction and enzymatic assay based on in vitro studies.

Graphical abstract: Self-assembly, doxorubicin-loading and antibacterial activity of well-defined ABA-type amphiphilic poly(N-vinylpyrrolidone)-b-poly(d,l-lactide)-b-poly(N-vinyl pyrrolidone) triblock copolymers

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Article information

DOI
https://doi.org/10.1039/C5RA23239B
Article type
Paper
Submitted
04 Nov 2015
Accepted
29 Feb 2016
First published
02 Mar 2016

RSC Adv., 2016,6, 25864-25876

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Self-assembly, doxorubicin-loading and antibacterial activity of well-defined ABA-type amphiphilic poly(N-vinylpyrrolidone)-b-poly(D,L-lactide)-b-poly(N-vinyl pyrrolidone) triblock copolymers

K. Ramesh, R. K. Gundampati, S. Singh, K. Mitra, A. Shukla, M. V. Jagannadham, D. Chattopadhyay, N. Misra and B. Ray, RSC Adv., 2016, 6, 25864 DOI: 10.1039/C5RA23239B

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