Issue 94, 2015
From the journal:

RSC Advances

Reactive oxygen species (ROS) mediated enhanced anti-candidal activity of ZnS–ZnO nanocomposites with low inhibitory concentrations

P. Suyana,a   S. Nishanth Kumar,b   Nimisha Madhavan,a   B. S. Dileep Kumar,bd   Balagopal N. Nair,c   A. Peer Mohamed,a   K. G. K. Warrierad  and  U. S. Hareesh ORCID logo *ad  

* Corresponding authors

a Material Science and Technology Division, National Institute for Interdisciplinary Science and Technology (CSIR-NIIST), Thiruvananthapuram-695019, India
E-mail: hareesh@niist.res.in
Fax: +91 471 2491712
Tel: +91 471 2535504

b Agroprocessing and Natural Products Division, National Institute for Interdisciplinary Science and Technology (CSIR-NIIST), Thiruvananthapuram-695019, India

c R&D Centre, Noritake Co. Limited, Aichi 470-0293, Japan

d Academy of Scientific and Innovative Research, New Delhi, India

Abstract

Enhanced antifungal activity against the yeast species Candida albicans, Candida tropicalis and Saccharomyces cerevisiae was displayed by ZnS–ZnO nanocomposites prepared by a simple precipitation technique. The antifungal activity was significantly more in the presence of indoor light than under dark conditions and was a clear confirmation of the inhibitory role of reactive oxygen species (ROS) generated in situ by the photocatalytic nanocomposites. The generation of ROS was further evidenced by flow cytometry results and membrane permeabilisation studies. Time kill assay and growth curve analysis indicated diminished antifungal activity under dark conditions due primarily to Zn2+ efflux in solution.

Graphical abstract: Reactive oxygen species (ROS) mediated enhanced anti-candidal activity of ZnS–ZnO nanocomposites with low inhibitory concentrations

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Article information

DOI
https://doi.org/10.1039/C5RA13316E
Article type
Paper
Submitted
07 Jul 2015
Accepted
04 Sep 2015
First published
04 Sep 2015

RSC Adv., 2015,5, 76718-76728

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Reactive oxygen species (ROS) mediated enhanced anti-candidal activity of ZnS–ZnO nanocomposites with low inhibitory concentrations

P. Suyana, S. Nishanth Kumar, N. Madhavan, B. S. Dileep Kumar, B. N. Nair, A. P. Mohamed, K. G. K. Warrier and U. S. Hareesh, RSC Adv., 2015, 5, 76718 DOI: 10.1039/C5RA13316E

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