Porous polystyrene spheres loaded self nano-emulsifying systems of rosuvastatin calcium†
Abstract
The aim of the study was to investigate potential of Solid Self Nano-Emulsifying Drug Delivery System (SNEDDS) for enhancing solubility and oral bioavailability of Rosuvastatin Calcium (RC). RC solubility was determined in different vehicles such as oils, surfactants and co-surfactants. Capmul MCM (oil), Tween 20 (surfactant) and PEG 200 were taken for the preparation of SNEDDS based upon the solubility of RC. Pseudo-ternary phase diagrams were constructed in order to identify efficient self-emulsifying regions. S-SNEDDS were prepared by adsorbing the optimized SNEDDS on to porous polystyrene spheres as a carrier. The S-SNEDDS formulated was free flowing and droplet size of the reconstituted nano-emulsion was almost unchanged after solidification. The prepared S-SNEDDS showed 98.92% release of RC at the end of 60 min, whereas pure RC exhibited only 38.6%. The Cmax and AUC0–t of the S-SNEDDS was about 7.97 and 7.91 fold higher than the pure drug respectively. This research study gives an overview of the S-SNEDDS as a hopeful choice to improve the oral bioavailability of RC.
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