Issue 56, 2015
From the journal:

RSC Advances

Anti-inflammatory sesquiterpenes from the medicinal herb Tanacetum sinaicum†

Mohamed-Elamir F. Hegazy,a   Ahmed R. Hamed,a   Tarik A. Mohamed,a   Abdessamad Debbab,b   Seikou Nakamura,c   Hisashi Matsudac  and  Paul W. Paré*d  

* Corresponding authors

a Phytochemistry Dept/Center Excellence for Advanced Sciences, National Research Centre, 33 El Bohouth St Dokki, P. O. 12622, Giza, Egypt

b Pharmaceutical Institut für Pharmazeutische Biologie und Biotechnologie, Heinrich-Heine-Universität Düsseldorf, D-40225 Düsseldorf, Germany

c Kyoto Pharmaceutical University, Yamashina-ku, Kyoto 607-8412, Japan

d Dept of Chemistry & Biochemistry Texas Tech University, Lubbock, TX 79409, USA
E-mail: Paul.pare@ttu.edu
Fax: +1 806 742 1289

Abstract

New sesquiterpenes tanacetolide A–C (1–3) were isolated from a Tanacetum sinaicum extract together with known compounds (4–10). The structures were elucidated on the basis of MS and NMR spectroscopic data. All the compounds were evaluated for the inhibition of inducible nitric oxide (NO) production in a mouse peritoneal macrophage system. Iso-seco-tanapartholide-3-O-methyl ether (4) produced potent inhibition of NO production (IC50 = 1.0 μM). At the protein expression level, 4 elicited concentration-dependant down-regulation of inducible nitric oxide synthase.

Graphical abstract: Anti-inflammatory sesquiterpenes from the medicinal herb Tanacetum sinaicum

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C5RA07511D
Article type
Paper
Submitted
24 Apr 2015
Accepted
12 May 2015
First published
13 May 2015

RSC Adv., 2015,5, 44895-44901

Author version available

Download author version (PDF)

Permissions

Request permissions

Anti-inflammatory sesquiterpenes from the medicinal herb Tanacetum sinaicum

M. F. Hegazy, A. R. Hamed, T. A. Mohamed, A. Debbab, S. Nakamura, H. Matsuda and P. W. Paré, RSC Adv., 2015, 5, 44895 DOI: 10.1039/C5RA07511D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements