Issue 21, 2015
From the journal:

Organic & Biomolecular Chemistry

Targeting intracellular bacteria with an extended cationic amphiphilic polyproline helix†

Manish Nepal,a   Shankar Thangamani,b   Mohamed N. Seleemb  and  Jean Chmielewski*a  

* Corresponding authors

a Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907-2027, USA
E-mail: chml@purdue.edu

b Department of Comparative Pathobiology, Purdue University, 627 Harrison Street, West Lafayette, IN 47907-2027, USA
E-mail: mseleem@purdue.edu

Abstract

An extended cationic and amphiphilic polyproline helix (CAPH) is described with a dual mode of action: effective cell penetration of human macrophages, and potent antimicrobial activity in vitro against both Gram-positive and negative pathogens, including Acinetobacter baumannii, Escherichia coli O157 and Bacillus anthracis. This dual action was successfully combined to clear pathogenic bacteria (Brucella and Salmonella) residing within macrophages.

Graphical abstract: Targeting intracellular bacteria with an extended cationic amphiphilic polyproline helix

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Article information

DOI
https://doi.org/10.1039/C5OB00227C
Article type
Paper
Submitted
02 Feb 2015
Accepted
20 Apr 2015
First published
20 Apr 2015

Org. Biomol. Chem., 2015,13, 5930-5936

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Targeting intracellular bacteria with an extended cationic amphiphilic polyproline helix

M. Nepal, S. Thangamani, M. N. Seleem and J. Chmielewski, Org. Biomol. Chem., 2015, 13, 5930 DOI: 10.1039/C5OB00227C

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