Issue 10, 2016
From the journal:

Chemical Communications

Switchable supramolecular catalysis using DNA-templated scaffolds†

Miguel Angel Aleman Garcia,a   Yuwei Hua  and  Itamar Willner*a  

* Corresponding authors

a Institute of Chemistry, The Minerva Center for Biohybrid Complex Systems, The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
E-mail: willnea@vms.huji.ac.il

Abstract

Switchable β-cyclodextrin (β-CD)-induced hydrolysis of m-tert-butylphenyl acetate is demonstrated in the presence of supramolecular β-CD/adamantane oligonucleotide scaffolds. In one system, a duplex between a β-CD-functionalized nucleic acid and an adamantane-nucleic acid leads to a switchable catalytic system. In a second system, a β-CD/adamantane duplex is cooperatively generated by K+-stabilized G-quadruplex units. The binding of hemin to the second system yields a bifunctional DNA scaffold with alternate catalytic functions.

Graphical abstract: Switchable supramolecular catalysis using DNA-templated scaffolds

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Article information

DOI
https://doi.org/10.1039/C5CC08873A
Article type
Communication
Submitted
26 Oct 2015
Accepted
01 Dec 2015
First published
24 Dec 2015

Chem. Commun., 2016,52, 2153-2156

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Switchable supramolecular catalysis using DNA-templated scaffolds

M. A. Aleman Garcia, Y. Hu and I. Willner, Chem. Commun., 2016, 52, 2153 DOI: 10.1039/C5CC08873A

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