Issue 48, 2014

Cationic imidazolium polymer monoliths for efficient solvent exchange, activation and fluorination on a continuous flow system

Abstract

Polystyrene-imidazolium (PS-Im+Cl) monolith was synthesized within a flow-through microfluidic chip and Teflon tubing for activating [18F]fluoride ions. The [18F]fluoride ions were trapped on the PS-Im+ monolith and were subsequently released with various phase-transfer catalysts (PTC) and carbonate or bicarbonate bases in microliter volumes of organic solvents containing 0.5% of water. The activated [18F]fluoride complex released from the PS-Im+ monolith was used to fluorinate various known PET probe precursors with diverse reactivity in a subsequent flow-through microfluidic chip without performing additional azeotropic distillation. The fluorination yields under the optimized condition for the protected [18F]FDG, protected [18F]FLT, 4-[18F]fluoroethylbenzoate, and [18F]fallypride were 93%, 96%, 77% and 73%, respectively. This method, utilizing the PS-Im+ monolith on a flow through microfluidic platform, enables the entire fluorine-18 radiochemistry to be performed on a flow-through microfluidic device within a shorter synthesis time and with fluorination efficiency that is comparable to or higher than conventional means.

Graphical abstract: Cationic imidazolium polymer monoliths for efficient solvent exchange, activation and fluorination on a continuous flow system

Supplementary files

Article information

Article type
Paper
Submitted
03 May 2014
Accepted
27 May 2014
First published
29 May 2014

RSC Adv., 2014,4, 25348-25356

Cationic imidazolium polymer monoliths for efficient solvent exchange, activation and fluorination on a continuous flow system

R. Ismail, J. Irribaren, M. R. Javed, A. Machness, R. Michael van Dam and P. Y. Keng, RSC Adv., 2014, 4, 25348 DOI: 10.1039/C4RA04064C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements