Issue 25, 2014
From the journal:

RSC Advances

Kurahyne, an acetylene-containing lipopeptide from a marine cyanobacterial assemblage of Lyngbya sp.†

Arihiro Iwasaki,a   Osamu Ohno,a   Shinpei Sumimoto,b   Shoichiro Sudab  and  Kiyotake Suenaga*a  

* Corresponding authors

a Department of Chemistry, Keio University, 3-14-1, Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan
E-mail: suenaga@chem.keio.ac.jp

b Faculty of Science, University of Ryukyus, 1 Senbaru, Nishihara, Okinawa 903-0213, Japan

Abstract

Kurahyne, a new acetylene-containing lipopeptide, was isolated from a cyanobacterial assemblage that mostly consisted of Lyngbya sp. Its structure was elucidated by spectroscopic analyses and chiral HPLC analyses of hydrolysis products. Kurahyne inhibited the growth of human cancer cells and induced apoptosis in HeLa cells, and it seemed to localize in mitochondria.

Graphical abstract: Kurahyne, an acetylene-containing lipopeptide from a marine cyanobacterial assemblage of Lyngbya sp.

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Article information

DOI
https://doi.org/10.1039/C4RA00132J
Article type
Communication
Submitted
07 Jan 2014
Accepted
20 Feb 2014
First published
21 Feb 2014
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2014,4, 12840-12843

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Kurahyne, an acetylene-containing lipopeptide from a marine cyanobacterial assemblage of Lyngbya sp.

A. Iwasaki, O. Ohno, S. Sumimoto, S. Suda and K. Suenaga, RSC Adv., 2014, 4, 12840 DOI: 10.1039/C4RA00132J

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