Issue 16, 2014
From the journal:

Nanoscale

Immunomodulatory properties of carbon nanotubes are able to compensate immune function dysregulation caused by microgravity conditions†

Claudia Crescio,a   Marco Orecchioni,b   Cécilia Ménard-Moyon,c   Francesco Sgarrella,b   Proto Pippia,a   Roberto Manetti,d   Alberto Bianco*c  and  Lucia Gemma Delogu*b  

* Corresponding authors

a Dipartimento di Scienze Biomediche, Università degli studi di Sassari, 07100 Sassari, Italy

b Dipartimento di Chimica e Farmacia, Università degli Studi di Sassari, 07100 Sassari, Italy
E-mail: lgdelogu@uniss.it

c CNRS, Institut de Biologie Moléculaire et Cellulaire, Laboratoire d'Immunopathologie et Chimie Thérapeutique, 67000 Strasbourg, France
E-mail: a.bianco@ibmc-cnrs.unistra.fr

d Dipartimento di Medicina Clinica, Sperimentale e Oncologica Università degli Studi di Sassari, 07100 Sassari, Italy

Abstract

Spaceflights lead to dysregulation of the immune cell functionality affecting the expression of activation markers and cytokine production. Short oxidized multi-walled carbon nanotubes functionalized by 1,3-dipolar cycloaddition have been reported to activate immune cells. In this Communication we have performed surface marker assays and multiplex ELISA on primary monocytes and T cells under microgravity. We have discovered that carbon nanotubes, through their immunostimulatory properties, are able to fight spaceflight immune system dysregulations.

Graphical abstract: Immunomodulatory properties of carbon nanotubes are able to compensate immune function dysregulation caused by microgravity conditions

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Article information

DOI
https://doi.org/10.1039/C4NR02711F
Article type
Communication
Submitted
17 May 2014
Accepted
14 Jun 2014
First published
16 Jun 2014

Nanoscale, 2014,6, 9599-9603

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Immunomodulatory properties of carbon nanotubes are able to compensate immune function dysregulation caused by microgravity conditions

C. Crescio, M. Orecchioni, C. Ménard-Moyon, F. Sgarrella, P. Pippia, R. Manetti, A. Bianco and L. G. Delogu, Nanoscale, 2014, 6, 9599 DOI: 10.1039/C4NR02711F

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