Issue 15, 2014
From the journal:

Nanoscale

Folic acid-functionalized up-conversion nanoparticles: toxicity studies in vivo and in vitro and targeted imaging applications†

Lining Sun,*a   Zuwu Wei,a   Haige Chen,*b   Jinliang Liu,a   Jianjian Guo,c   Ming Cao,b   Tieqiao Wenc  and  Liyi Shi*a  

* Corresponding authors

a Research Center of Nano Science and Technology, Shanghai University, Shanghai 200444, P. R. China
E-mail: lnsun@shu.edu.cn, shiliyi@shu.edu.cn
Tel: +86-21-66137153

b Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, P. R. China
E-mail: kirbyhaige@aliyun.com

c Laboratory of Molecular Neural Biology, School of Life Sciences, Shanghai University, Shanghai 200444, P. R. China

Abstract

Folate receptors (FRs) are overexpressed on a variety of human cancer cells and tissues, including cancers of the breast, ovaries, endometrium, and brain. This over-expression of FRs can be used to target folate-linked imaging specifically to FR-expressing tumors. Fluorescence is emerging as a powerful new modality for molecular imaging in both the diagnosis and treatment of disease. Combining innovative molecular biology and chemistry, we prepared three kinds of folate-targeted up-conversion nanoparticles as imaging agents (UCNC-FA: UCNC-Er-FA, UCNC-Tm-FA, and UCNC-Er,Tm-FA). In vivo and in vitro toxicity studies showed that these nanoparticles have both good biocompatibility and low toxicity. Moreover, the up-conversion luminescence imaging indicated that they have good targeting to HeLa cells and can therefore serve as potential fluorescent contrast agents.

Graphical abstract: Folic acid-functionalized up-conversion nanoparticles: toxicity studies in vivo and in vitro and targeted imaging applications

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Article information

DOI
https://doi.org/10.1039/C4NR02312A
Article type
Paper
Submitted
29 Apr 2014
Accepted
29 May 2014
First published
24 Jun 2014

Nanoscale, 2014,6, 8878-8883

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Folic acid-functionalized up-conversion nanoparticles: toxicity studies in vivo and in vitro and targeted imaging applications

L. Sun, Z. Wei, H. Chen, J. Liu, J. Guo, M. Cao, T. Wen and L. Shi, Nanoscale, 2014, 6, 8878 DOI: 10.1039/C4NR02312A

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