Issue 7, 2015

Harnessing medically relevant metals onto water-soluble subphthalocyanines: towards bimodal imaging and theranostics

Abstract

Subphthalocyanine (SubPc), a putative fluorophore for optical imaging (OI), was conjugated to chelating ligands (DOTA, DTPA) affording water-soluble conjugates complexed with (non-radioactive) metals relevant to the following medical imaging techniques/therapies: MRI (Gd), PET (Cu, Ga), SPECT (In, Ga, Lu), RIT (Cu, Lu, Y), and NCT (Gd). Magneto-optical properties of ditopic gadolinium species (and optical properties of other metal containing species) were examined (brightness (ε × ΦF) and relaxivity R1) and fluorescence confocal/biphoton microscopy studies were conducted.

Graphical abstract: Harnessing medically relevant metals onto water-soluble subphthalocyanines: towards bimodal imaging and theranostics

Supplementary files

Article information

Article type
Paper
Submitted
17 Nov 2014
Accepted
22 Dec 2014
First published
22 Dec 2014

Dalton Trans., 2015,44, 3200-3208

Author version available

Harnessing medically relevant metals onto water-soluble subphthalocyanines: towards bimodal imaging and theranostics

Y. Bernhard, P. Winckler, J. Perrier-Cornet and R. A. Decréau, Dalton Trans., 2015, 44, 3200 DOI: 10.1039/C4DT03536D

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