Issue 48, 2014
From the journal:

Physical Chemistry Chemical Physics

The structure of insulin at the air/water interface: monomers or dimers?

S. Mauri,ab   T. Weidnerb  and  H. Arnolds*a  

* Corresponding authors

a The University of Liverpool, Chemistry Department, Surface Science Research Centre, Liverpool, UK
E-mail: Heike.Arnolds@liv.ac.uk

b Max Planck Institute for Polymer Research, Mainz, Germany

Abstract

The hydrophobic character of the air/water interface affects the oligomeric composition of insulin. By using interface-specific vibrational sum frequency spectroscopy and calculations of insulin monomer and dimer second-order nonlinear susceptibilities χ(2), we show that insulin monomers segregate to the air/water interface.

Graphical abstract: The structure of insulin at the air/water interface: monomers or dimers?

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Article information

DOI
https://doi.org/10.1039/C4CP04926H
Article type
Communication
Submitted
27 Oct 2014
Accepted
28 Oct 2014
First published
03 Nov 2014
This article is Open Access
Creative Commons BY license

Phys. Chem. Chem. Phys., 2014,16, 26722-26724

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The structure of insulin at the air/water interface: monomers or dimers?

S. Mauri, T. Weidner and H. Arnolds, Phys. Chem. Chem. Phys., 2014, 16, 26722 DOI: 10.1039/C4CP04926H

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