Issue 36, 2014
From the journal:

Chemical Communications

Direct N-acylation of azoles via a metal-free catalyzed oxidative cross-coupling strategy†

Jingjing Zhao,ab   Pan Li,a   Chungu Xiaa  and  Fuwei Li*a  

* Corresponding authors

a State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, China
E-mail: fuweili@licp.cas.cn
Fax: +86-931-4968129

b Graduate University of Chinese Academy of Sciences, Beijing, China

Abstract

The KI-catalyzed N-acylation of azoles via direct oxidative coupling of C–H and N–H bonds has been developed. It could be smoothly scaled up to gram synthesis of acyl azoles. The reaction occurred by the coupling of acyl radicals and azoles to form the acyl azole radical anion, followed by its further oxidation.

Graphical abstract: Direct N-acylation of azoles via a metal-free catalyzed oxidative cross-coupling strategy

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C4CC01587H
Article type
Communication
Submitted
03 Mar 2014
Accepted
18 Mar 2014
First published
18 Mar 2014

Chem. Commun., 2014,50, 4751-4754

Permissions

Request permissions

Direct N-acylation of azoles via a metal-free catalyzed oxidative cross-coupling strategy

J. Zhao, P. Li, C. Xia and F. Li, Chem. Commun., 2014, 50, 4751 DOI: 10.1039/C4CC01587H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements