Issue 43, 2013
From the journal:

RSC Advances

Design, synthesis, and preliminary biological evaluation of novel ketone derivatives of shikimic acid†

Min Jiang,ab   Bing Xiong,b   Yu-mei Shen*a  and  Chunhao Yang*b  

* Corresponding authors

a Shanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P.R. China
E-mail: yumeishen@sjtu.edu.cn

b State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, SIBS, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, P.R. China
E-mail: chyang@simm.ac.cn

Abstract

We herein report the discovery of novel shikimic acid derivatives via Suzuki coupling and Liebeskind–Srogl reaction. Fourteen compounds were synthesized and evaluated against M. tuberculosis H37Rv (ATCC 95054). Most of these compounds displayed activities against M. tuberculosis with MIC ranging from 4 to 16 μg mL−1. These substances are promising antimycobacterial prototypes.

Graphical abstract: Design, synthesis, and preliminary biological evaluation of novel ketone derivatives of shikimic acid

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Article information

DOI
https://doi.org/10.1039/C3RA43755H
Article type
Paper
Submitted
07 Aug 2013
Accepted
29 Aug 2013
First published
30 Aug 2013

RSC Adv., 2013,3, 20599-20605

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Design, synthesis, and preliminary biological evaluation of novel ketone derivatives of shikimic acid

M. Jiang, B. Xiong, Y. Shen and C. Yang, RSC Adv., 2013, 3, 20599 DOI: 10.1039/C3RA43755H

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