Issue 73, 2013

Ni2+ and Cu2+ complexes of a phenanthroline-based ligand bind to G-quadruplexes at non-overlapping sites

Abstract

Transition metal complexes allow fine tuning of DNA binding affinity and selectivity. Here we report on the nucleic acid recognition properties of a phenanthroline-based ligand coordinated to Ni2+ or Cu2+. The resulting complexes clearly bind to telomeric G-quadruplexes at different sites according to the nature of the bound metal ion.

Graphical abstract: Ni2+ and Cu2+ complexes of a phenanthroline-based ligand bind to G-quadruplexes at non-overlapping sites

Supplementary files

Article information

Article type
Communication
Submitted
11 Jun 2013
Accepted
17 Jul 2013
First published
18 Jul 2013

Chem. Commun., 2013,49, 8057-8059

Ni2+ and Cu2+ complexes of a phenanthroline-based ligand bind to G-quadruplexes at non-overlapping sites

S. Bianco, C. Musetti, A. P. Krapcho, M. Palumbo and C. Sissi, Chem. Commun., 2013, 49, 8057 DOI: 10.1039/C3CC44382E

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