Issue 62, 2013
From the journal:

Chemical Communications

PEG-sheddable polyplex micelles as smart gene carriers based on MMP-cleavable peptide-linked block copolymers†

Junjie Li,a   Zhishen Ge*a  and  Shiyong Liu*a  

* Corresponding authors

a CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China
E-mail: gezs@ustc.edu.cn, sliu@ustc.edu.cn
Fax: +86-551-63603670
Tel: +86-551-63603670

Abstract

A matrix metalloproteinase-cleavable peptide-linked block copolymer was fabricated and utilized to construct PEG-sheddable polyplex micelles as smart gene delivery vectors, which were demonstrated to exhibit higher cellular uptake, improved endosomal escape, and high-efficiency gene transfection in the presence of matrix metalloproteinase-2.

Graphical abstract: PEG-sheddable polyplex micelles as smart gene carriers based on MMP-cleavable peptide-linked block copolymers

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Article information

DOI
https://doi.org/10.1039/C3CC43576H
Article type
Communication
Submitted
13 May 2013
Accepted
12 Jun 2013
First published
12 Jun 2013

Chem. Commun., 2013,49, 6974-6976

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PEG-sheddable polyplex micelles as smart gene carriers based on MMP-cleavable peptide-linked block copolymers

J. Li, Z. Ge and S. Liu, Chem. Commun., 2013, 49, 6974 DOI: 10.1039/C3CC43576H

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