Issue 66, 2013
From the journal:

Chemical Communications

Morpholino-decorated long circulating polymeric micelles with the function of surface charge transition triggered by pH changes†

Yan Zhang,a   Chenhong Wang,b   Chuang Xu,a   Cuiping Yang,b   Zhenqing Zhang,b   Husheng Yan*a  and  Keliang Liu*b  

* Corresponding authors

a Key Laboratory of Functional Polymer Materials (Ministry of Education), Institute of Polymer Chemistry, Nankai University, Tianjin 300071, China
E-mail: yanhs@nankai.edu.cn

b Beijing Institute of Pharmacology and Toxicology, 27 Taiping Road, Beijing 100850, China
E-mail: keliangliu55@126.com

Abstract

Micelles with surface morpholino groups were stealthy at blood and normal tissue pH (7.4) due to the unprotonated hydrophilic morpholino groups on the surfaces. At tumor pH (<7), the micelle surfaces were positively charged because of the protonation of the morpholino groups, which promoted the cellular uptake of the micelles.

Graphical abstract: Morpholino-decorated long circulating polymeric micelles with the function of surface charge transition triggered by pH changes

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Article information

DOI
https://doi.org/10.1039/C3CC43334J
Article type
Communication
Submitted
05 May 2013
Accepted
22 Jun 2013
First published
24 Jun 2013

Chem. Commun., 2013,49, 7286-7288

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Morpholino-decorated long circulating polymeric micelles with the function of surface charge transition triggered by pH changes

Y. Zhang, C. Wang, C. Xu, C. Yang, Z. Zhang, H. Yan and K. Liu, Chem. Commun., 2013, 49, 7286 DOI: 10.1039/C3CC43334J

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