Piperidine-mediated aspartimide and subsequent piperidide formation, during Fmoc-based synthesis of sensitive aspartyl (β-tert-butyl ester, OBut)-containing peptides, is completely suppressed by the use of Hmb protection of the aspartyl amide bond.
M. Quibell, D. Owen, L. C. Packman and T. Johnson, J. Chem. Soc., Chem. Commun., 1994, 2343 DOI: 10.1039/C39940002343
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