Stereoselective intramolecular nitrile oxide cycloaddition to chiral allyl ethers
Abstract
Intramolecular nitrile oxide cycloaddition reactions on (Z)- and (E)-chiral allyl ethers occur with poor to good stereoselectivity (diastereoisomeric ratios up to 86: 14), which depends on the double bond configuration as well as on steric and stereoelectronic effects.