Issue 5, 2013
From the journal:

Journal of Materials Chemistry B

High payload Gd(iii) encapsulated in hollow silica nanospheres for high resolution magnetic resonance imaging†

Wan-Ing Lin,a   Chien-Yuan Lin,b   Yu-Shen Lin,a   Si-Han Wu,a   Yu-Ru Huang,a   Yann Hung,a   Chen Changb  and  Chung-Yuan Mou*a  

* Corresponding authors

a Department of Chemistry, National Taiwan University, Taipei, Taiwan 10617
E-mail: cymou@ntu.edu.tw
Fax: +886-2-23660954

b Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan 11529
E-mail: bmcchen@ibms.sinica.edu.tw
Fax: +886-2-27887641
Tel: +886-2-27899027

Abstract

For clear MR imaging of blood vessels, a long blood circulation time of effective T1 contrast agents is necessary. Nanoparticulate MR contrast agents are much more effective owing to their enhanced relaxivity, a result of reduced tumbling rates, and large payloads of active magnetic species. PEGylated yolk–shell silica nanospheres containing high payloads of Gd(III) with cross-linking ligands are synthesized and evaluated as a blood-pool magnetic resonance contrast agent. The hydrophilic PEG coating and the microporous silica shell allow water exchange while keeping the multi-nuclear Gd species from leaching out. These Gd(III)-containing yolk–shell silica nanoparticles with PEGylated surfaces give excellent resolution and contrast in magnetic resonance angiography images of vasculature in rat brains.

Graphical abstract: High payload Gd(iii) encapsulated in hollow silica nanospheres for high resolution magnetic resonance imaging

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Article information

DOI
https://doi.org/10.1039/C2TB00283C
Article type
Paper
Submitted
20 Oct 2012
Accepted
06 Dec 2012
First published
07 Dec 2012

J. Mater. Chem. B, 2013,1, 639-645

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High payload Gd(III) encapsulated in hollow silica nanospheres for high resolution magnetic resonance imaging

W. Lin, C. Lin, Y. Lin, S. Wu, Y. Huang, Y. Hung, C. Chang and C. Mou, J. Mater. Chem. B, 2013, 1, 639 DOI: 10.1039/C2TB00283C

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