Issue 18, 2012
From the journal:

Soft Matter

Dual signal glucose reporter based on inverse opal conducting hydrogel films

Lu Jin,a   Yuanjin Zhao,a   Xing Liu,a   Youli Wang,c   Baofen Ye,a   Zhuoying Xiea  and  Zhongze Gu*ab  

* Corresponding authors

a State Key Laboratory of Bioelectronics, Biological Science and Medical Engineering Department, Southeast University, Nanjing 210096, P. R. China
E-mail: gu@seu.edu.cn
Fax: +86 25 83795635
Tel: +86 25 83795635

b Suzhou Key Laboratory of Environment and Biosafety, Suzhou Academy of Southeast University, Dushuhu Lake Higher Education Town, Suzhou 215123, P. R. China

c Nanjing Medical University Subordinated Nanjing No.1 Hospital, Nanjing 210006, P.R.China

Abstract

A novel glucose responsive hydrogel film possessing inverse opal structure and conducting property was developed, based on the principle of enzyme-catalytic redox reaction. The film can report glucose concentration via optical and electrochemical signals, respectively. To fabricate the sensor film, SiO2 crystalline colloidal array was utilized as a sacrificed template to endow the polyacrylamide(PAAm) hydrogel with non-closed-packed inverse opal structure, then conductive polymer (CP) poly(3,4-ethylenedioxythiophene) PEDOT was in situ chemically oxypolymerized to form interpenetrated network (IPN) within the hydrogel. The supporting matrix was activated by partial hydrolysis of amide groups on the backbone, to serve as bonding sites for glucose oxidase (GOx) and ion responsive elements. The changes in the hydrogel microenvironment caused by the catalytic product of glucose induced shrinkage of the hydrogel and a corresponding blue shift of the reflection peak of the film. Meanwhile, the hydrogel acted as a flexible amperometric electrode to sense current change. Linear response upon concentration of glucose ranged from 1 mM to 12 mM. Glucose was exhibited optically and electrically confirming a mutual regulation capacity to achieve better anti-interference performance.

Graphical abstract: Dual signal glucose reporter based on inverse opal conducting hydrogel films

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Article information

DOI
https://doi.org/10.1039/C2SM06954G
Article type
Paper
Submitted
13 Oct 2011
Accepted
30 Jan 2012
First published
29 Feb 2012

Soft Matter, 2012,8, 4911-4917

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Dual signal glucose reporter based on inverse opal conducting hydrogel films

L. Jin, Y. Zhao, X. Liu, Y. Wang, B. Ye, Z. Xie and Z. Gu, Soft Matter, 2012, 8, 4911 DOI: 10.1039/C2SM06954G

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