Issue 3, 2013

Phyto-power dietary supplement potently inhibits dimethylnitrosamine-induced liver fibrosis in rats

Abstract

Curcumin has been extensively studied for its therapeutic effects in a variety of disorders. Fermented soy consumption is associated with a low incidence rate of chronic diseases in many Asian countries. The aim of this study was to investigate the potential underlying mechanisms of the effect of a phyto-power dietary supplement on liver fibrosis. Sprague-Dawley rats were intraperitoneally injected with dimethylnitrosamine (DMN; 10 mg kg−1) three times a week for four consecutive weeks. A phyto-power dietary supplement (50 or 100 mg kg−1) was administered by oral gavage daily for four weeks. Liver morphology, function, and fibrotic status were examined in DMN induced hepatic fibrogenesis. However, a phyto-power dietary supplement alleviated liver damage as indicated by histopathological examination of the α-smooth muscle actin (α-SMA) and collagen I, accompanied by the concomitant reduction of transforming growth factor-β1 (TGF-β1) and matrix metalloproteinase 2 (MMP2). These data indicate that the phyto-power dietary supplement may inhibit the TGF-β1/Smad signaling and relieve liver damage in experimental fibrosis.

Graphical abstract: Phyto-power dietary supplement potently inhibits dimethylnitrosamine-induced liver fibrosis in rats

Article information

Article type
Paper
Submitted
31 Oct 2012
Accepted
08 Dec 2012
First published
10 Dec 2012

Food Funct., 2013,4, 470-475

Phyto-power dietary supplement potently inhibits dimethylnitrosamine-induced liver fibrosis in rats

M. Lee, M. Tsai, P. Sun, L. Chien, A. Cheng, N. J. Ma, C. Ho and M. Pan, Food Funct., 2013, 4, 470 DOI: 10.1039/C2FO30306J

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