Issue 33, 2012
From the journal:

Dalton Transactions

Self-assembly and alterable relaxivity of an organic cation-encapsulated gadolinium-containing polyoxometalate†

Yinglin Wang,a   Shengyan Zhou,b   Daliang Kong,b   Haishan Yang,b   Wenqiang Chai,c   Ulrich Kortzd  and  Lixin Wu*a  

* Corresponding authors

a State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun, P.R. China
E-mail: wulx@jlu.edu.cn
Fax: (+86) 431-8519-3421

b Radiology Department, China-Japan Union Hospital of Jilin University, Changchun, Jilin, P.R. China

c Institut für Physikalische Chemie, Johannes Gutenberg-Universität, Mainz, Jakob-Welder-Weg 11, D-55128 Mainz, Germany

d School of Engineering and Science, Jacobs University Bremen, P. O. Box 750 561, 28725 Bremen, Germany

Abstract

A new amphiphilic molecule bearing poly(ethylene oxide) (PEO) and quaternary ammonium group, was designed and synthesized to encapsulate paramagnetic GdIII-containing polyoxometalate (Gd-POM) through electrostatic interaction for obtaining a water-soluble organic–inorganic hybrid building block based on POM. The yielding organic cation-encapsulated Gd-POM (OCEP-Gd) complex exhibited water-solubility and amphiphility, leading to the spontaneous self-assembly into a regular vesicular structure with PEO chains towards water phase and POM units locating at the middle. The vesicular aggregate which has a regular monolayer structure, was further studied by means of dynamic light scattering, transmission electron microscopy, and X-ray diffraction. Due to the synergy of different building units, the self-assembly of the complexes was demonstrated to be efficient to adjust the ability of Gd-POM to accelerate relaxation of water-proton, which results from the paramagnetic property of Gd-POM, to a large extent. The present work provides a new methodology to obtain water-soluble hybrid building blocks based on POM, which may generate more hybrid self-assembly structures in aqueous solution and further direct POM-based materials towards biomedical applications.

Graphical abstract: Self-assembly and alterable relaxivity of an organic cation-encapsulated gadolinium-containing polyoxometalate

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Article information

DOI
https://doi.org/10.1039/C2DT30641G
Article type
Paper
Submitted
21 Mar 2012
Accepted
15 May 2012
First published
16 May 2012

Dalton Trans., 2012,41, 10052-10059

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Self-assembly and alterable relaxivity of an organic cation-encapsulated gadolinium-containing polyoxometalate

Y. Wang, S. Zhou, D. Kong, H. Yang, W. Chai, U. Kortz and L. Wu, Dalton Trans., 2012, 41, 10052 DOI: 10.1039/C2DT30641G

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