Issue 28, 2012
From the journal:

Dalton Transactions

The syntheses and characterizations of molybdenum(vi) complexes with catechol and 2,3-dihydroxynaphthalene, and the structure–effect relationship in their in vitro anticancer activities†

Jun Feng,a   Xiao-ming Lu,*a   Guo Wang,a   Shi-zhen Dua  and  Yi-feng Chenga  

* Corresponding authors

a Department of Chemistry, Capital Normal University, Beijing, China
E-mail: lu-xiaoming@126.com
Fax: +86 010 8814 2149
Tel: +86 010 8814 2149

Abstract

The reactions of (NH4)2Mo2O7·2H2O with polyhydroxy phenols (catechol or 2,3-dihydroxynaphthalene) and ethylenediamine (en), trimethylenediamine (tn), 1,2-propanediamine (pn), triethylamine (Et3N) respectively, in the mixed-solvent of MeCN–EtOH–amine, have resulted in five molybdenum(VI) complexes, (enH2)[MoVIO3(cat)(en)] (1), (tnH2)[MoVIO3(cat)(tn)] (2), (enH)2[MoVIO2(cat)2](en)0.5 (3), (pnH2)2[MoVIO2(cat)2] (4) and (HNEt3)2[MoVIO2(C10H8O2)2] (5), of which the structural features were investigated by X-ray diffraction. MTT assay tests indicated that their inhibition ratios against human cancer cells decreased in the order: (1) ≈ (2) > (3) ≈ (4) > (5), i.e. the activities decreased when the chelation number or the size of the aromatic ligand increased, which was consistent with the Gibbs free energies (ΔG) determined from theoretical computations by Gaussian 03. The mechanisms behind this trend were discussed preliminarily.

Graphical abstract: The syntheses and characterizations of molybdenum(vi) complexes with catechol and 2,3-dihydroxynaphthalene, and the structure–effect relationship in their in vitro anticancer activities

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Article information

DOI
https://doi.org/10.1039/C2DT30395G
Article type
Paper
Submitted
20 Feb 2012
Accepted
17 May 2012
First published
18 May 2012

Dalton Trans., 2012,41, 8697-8702

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The syntheses and characterizations of molybdenum(VI) complexes with catechol and 2,3-dihydroxynaphthalene, and the structure–effect relationship in their in vitro anticancer activities

J. Feng, X. Lu, G. Wang, S. Du and Y. Cheng, Dalton Trans., 2012, 41, 8697 DOI: 10.1039/C2DT30395G

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