Issue 8, 2012
From the journal:

Chemical Communications

Aptamer optical biosensor without bio-breakage using upconversion nanoparticles as donors†

Kai Song,‡a   Xianggui Kong,*ab   Xiaomin Liu,‡ab   Youlin Zhang,a   Qinghui Zeng,a   Langping Tu,a   Zhan Shid  and  Hong Zhang*c  

* Corresponding authors

a Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, P. R. China
E-mail: xgkong14@ciomp.ac.cn

b Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Science, P. R. China

c Van't Hoff Institute for Molecular Sciences, University of Amsterdam, The Netherlands
E-mail: h.zhang@uva.nl

d State Key Laboratory of Inorganic Synthesis & Preparative Chemistry, College of Chemistry, Jilin University, P. R. China

Abstract

LRET-based optical biosensor of an aptamer-upconversion conjugate was constructed. It is demonstrated that photosensitized breakage and damage of aptamers are eliminated by employing UCNPs as donors, and the as-designed biosensor is specific and sensitive in the detection of ATP.

Graphical abstract: Aptamer optical biosensor without bio-breakage using upconversion nanoparticles as donors

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Article information

DOI
https://doi.org/10.1039/C2CC16817K
Article type
Communication
Submitted
03 Nov 2011
Accepted
22 Nov 2011
First published
24 Nov 2011

Chem. Commun., 2012,48, 1156-1158

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Aptamer optical biosensor without bio-breakage using upconversion nanoparticles as donors

K. Song, X. Kong, X. Liu, Y. Zhang, Q. Zeng, L. Tu, Z. Shi and H. Zhang, Chem. Commun., 2012, 48, 1156 DOI: 10.1039/C2CC16817K

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