Issue 11, 2012
From the journal:

Analytical Methods

Quality assessment and origin tracing of Guangdong Liangcha granules using direct mass spectrometry fingerprinting†

Jiewei Deng,‡a   Chunlin Fan,‡b   Zhengjin Jiang,c   Wencai Ye*b  and  Yunyun Yang*a  

* Corresponding authors

a Guangdong Provincial Public Laboratory of Analysis and Testing Technology, China National Analytical Center Guangzhou, China
E-mail: yy_yang@vip.126.com
Fax: +86 20 8768 1384
Tel: +86 20 3765 6885 823

b Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, China
E-mail: chywc@yahoo.com.cn
Fax: +86 20 8522 1559
Tel: +86 20 8522 0936

c Department of Pharmacy and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drug Research, Jinan University, Guangzhou, China

Abstract

A novel fingerprinting approach for quality assessment and origin tracing of Guangdong Liangcha granules (GLG) by electrospray ionization time-of-flight mass spectrometry (ESI-TOF-MS) has been established. A negative-ion ESI-TOF spectrum gave the best chemical information and was most suitable to construct the chemical profile fingerprinting of GLG. Using high-resolution TOF-MS, 61 common mass spectral peaks based on the major constituents present in GLG were accurately and simultaneously detected without any chromatographic separation, providing valuable information for overall assessment of the quality and differentiation of the origin of the preparation. Six sources of commercial GLG products produced by five different manufacturers have been successfully differentiated, according to the principal component analysis of 61 common mass spectral peaks, and the stability of them was also assessed. The results of our experimental data demonstrated that ESI-TOF-MS fingerprinting is a useful tool for rapid pharmaceutical analysis, with promising prospects for overall quality assessment and origin differentiation of commercial pharmaceutical products.

Graphical abstract: Quality assessment and origin tracing of Guangdong Liangcha granules using direct mass spectrometry fingerprinting

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Article information

DOI
https://doi.org/10.1039/C2AY25651G
Article type
Paper
Submitted
25 Jun 2012
Accepted
16 Aug 2012
First published
17 Aug 2012

Anal. Methods, 2012,4, 3638-3645

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Quality assessment and origin tracing of Guangdong Liangcha granules using direct mass spectrometry fingerprinting

J. Deng, C. Fan, Z. Jiang, W. Ye and Y. Yang, Anal. Methods, 2012, 4, 3638 DOI: 10.1039/C2AY25651G

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