Issue 1, 2012
From the journal:

MedChemComm

Selective inhibition of E. coli1-deoxy-d-xylulose-5-phosphate synthase by acetylphosphonates†

Jessica M. Smith,‡a   Ryan J. Vierling‡a  and  Caren Freel Meyers*a  

* Corresponding authors

a Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
E-mail: cmeyers@jhmi.edu

Abstract

DXP synthase catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate, an essential precursor in pathogen isoprenoid biosynthesis. The selective inhibition of this ThDP-dependent transformation is a challenging goal in the development of isoprenoid biosynthesis inhibitors. Potent, selective inhibitors could lead to new anti-infective agents. Here, we demonstrate selective inhibition of E. coliDXP synthase by butylacetylphosphonate.

Graphical abstract: Selective inhibition of E. coli1-deoxy-d-xylulose-5-phosphate synthase by acetylphosphonates

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Article information

DOI
https://doi.org/10.1039/C1MD00233C
Article type
Concise Article
Submitted
13 Sep 2011
Accepted
19 Sep 2011
First published
26 Oct 2011

Med. Chem. Commun., 2012,3, 65-67

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Selective inhibition of E. coli1-deoxy-D-xylulose-5-phosphate synthase by acetylphosphonates

J. M. Smith, R. J. Vierling and C. F. Meyers, Med. Chem. Commun., 2012, 3, 65 DOI: 10.1039/C1MD00233C

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