Issue 33, 2011

Dextran-coated magnetic nanoclusters as highly sensitive contrast agents for magnetic resonance imaging of inflammatory macrophages

Abstract

We fabricated dextran-coated magnetic nanoclusters (Dex-MNCs) for targeted magnetic resonance (MR) imaging of inflammatory macrophages. Dex-MNCs were prepared through encapsulation of hydrophobic magnetic nanocrystals (MNCs) by pyrenyl dextran in order that MNCs could achieve increased colloidal stability in aqueous phase as well as strongly interact with macrophages. Dex-MNCs exhibited biocompatibility and sufficient targeting efficiency against macrophages with strengthened MR contrast effect from in vitro/in vivo studies. Considering these results, we confirmed that Dex-MNCs could accurately detect inflammatory macrophagevia MR imaging.

Graphical abstract: Dextran-coated magnetic nanoclusters as highly sensitive contrast agents for magnetic resonance imaging of inflammatory macrophages

Article information

Article type
Paper
Submitted
21 Feb 2011
Accepted
06 Jun 2011
First published
21 Jul 2011

J. Mater. Chem., 2011,21, 12473-12478

Dextran-coated magnetic nanoclusters as highly sensitive contrast agents for magnetic resonance imaging of inflammatory macrophages

E. Lim, E. Jang, B. Kim, J. Choi, K. Lee, J. Suh, Y. Huh and S. Haam, J. Mater. Chem., 2011, 21, 12473 DOI: 10.1039/C1JM10764J

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