Issue 35, 2011
From the journal:

Journal of Materials Chemistry

Induction heating studies of Fe3O4 magnetic nanoparticles capped with oleic acid and polyethylene glycol for hyperthermia†

Runa Ghosh,‡a   Lina Pradhan,‡b   Yensenbam Priyabala Devi,a   S. S. Meena,c   R. Tewari,d   Amit Kumar,b   Sachil Sharma,e   N. S. Gajbhiye,e   R. K. Vatsa,a   Badri N. Pandey*b  and  R. S. Ningthoujam*a  

* Corresponding authors

a Chemistry Division, Bhabha Atomic Research Centre, Mumbai, India
E-mail: rsn@barc.gov.in, nraghu_mani@yahoo.co.in
Fax: +91-22-2550 5151
Tel: +91-22-2559 2321

b Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Mumbai, India
E-mail: bnp@barc.gov.in, badrinarain@yahoo.co.in
Fax: +91-22-2550 5151
Tel: +91-22-2559 5043

c Solid State Physics Division, Bhabha Atomic Research Centre, Mumbai, India

d Material Science Division, Bhabha Atomic Research Centre, Mumbai, India

e Department of Chemistry, Indian Institute of Technology, Kanpur, India

Abstract

Fe3O4 magnetic nanoparticles (Fe3O4-MN) capped with either oleic acid (Fe3O4-OA-MN) or polyethylene glycol (Fe3O4-PEG-MN) were prepared by a co-precipitation method. From X-ray diffraction studies, the average crystallite sizes of Fe3O4-MN, Fe3O4-OA-MN and Fe3O4-PEG-MN were found to be 12, 6 and 8 nm, respectively. A reduction in the agglomeration of particles was observed when the magnetic nanoparticles (MN) were capped with oleic acid (OA) and polyethylene glycol (PEG), as confirmed by a transmission electron microscopy study. Magnetization of these MN was almost zero at room temperature in the absence of an applied magnetic field, indicating their superparamagnetic behavior. Magnetization was lower and the superparamagnetic fraction was higher for Fe3O4-OA-MN and Fe3O4-PEG-MN compared to Fe3O4-MN studied using a Mössbauer spectrometer. Compared to the control, an increased killing (35%) was observed in human breast cancer cells (MCF7) after Fe3O4-OA-MN treatment, which was further enhanced (65%) under induction heating conditions. However, MCF7 cells treated with Fe3O4-MN or Fe3O4-PEG-MN showed 5–10% killing after induction heating. These results showed the characterization of MN with different lipophilicity and suggests their suitability for hyperthermia applications in cancer therapy.

Graphical abstract: Induction heating studies of Fe3O4 magnetic nanoparticles capped with oleic acid and polyethylene glycol for hyperthermia

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Article information

DOI
https://doi.org/10.1039/C1JM10092K
Article type
Paper
Submitted
07 Jan 2011
Accepted
13 Jun 2011
First published
08 Aug 2011

J. Mater. Chem., 2011,21, 13388-13398

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Induction heating studies of Fe3O4 magnetic nanoparticles capped with oleic acid and polyethylene glycol for hyperthermia

R. Ghosh, L. Pradhan, Y. P. Devi, S. S. Meena, R. Tewari, A. Kumar, S. Sharma, N. S. Gajbhiye, R. K. Vatsa, B. N. Pandey and R. S. Ningthoujam, J. Mater. Chem., 2011, 21, 13388 DOI: 10.1039/C1JM10092K

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