Issue 47, 2011
From the journal:

Chemical Communications

Use of alkyl 2,4,6-triisopropylbenzoates in the asymmetric homologation of challenging boronic esters†

Robin Larouche-Gauthier,a   Catherine J. Fletcher,a   Irantzu Coutoa  and  Varinder K. Aggarwal*a  

* Corresponding authors

a School of Chemistry, University of Bristol, Cantock's Close, Bristol, UK
E-mail: v.aggarwal@bristol.ac.uk
Fax: +44 (0)117 929 8611
Tel: +44 (0)117 954 6315

Abstract

(−)-Sparteine induced lithiation of primary 2,4,6-triisopropylbenzoates and subsequent homologation of boronic esters is reported. A comparative study with lithiated N,N-diisopropylcarbamates has demonstrated the superiority of the hindered benzoate.

Graphical abstract: Use of alkyl 2,4,6-triisopropylbenzoates in the asymmetric homologation of challenging boronic esters

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Article information

DOI
https://doi.org/10.1039/C1CC14469C
Article type
Communication
Submitted
22 Jul 2011
Accepted
17 Aug 2011
First published
05 Sep 2011

Chem. Commun., 2011,47, 12592-12594

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Use of alkyl 2,4,6-triisopropylbenzoates in the asymmetric homologation of challenging boronic esters

R. Larouche-Gauthier, C. J. Fletcher, I. Couto and V. K. Aggarwal, Chem. Commun., 2011, 47, 12592 DOI: 10.1039/C1CC14469C

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