Issue 4, 2012

Design of multivalent galactosyl carborane as a targeting specific agent for potential application to boron neutron capture therapy

Abstract

A multivalent galactosyl carborane derivative 10 (dendritic glyco-borane, DGB) was synthesized and demonstrated as a potential cell-targeting agent in BNCT with HepG2 cells. DGB 10 improved the delivery of boron to HepG2 cells and neutron irradiation data show DGB 10 with ten-fold improvement at killing the HepG2 cells over BSH.

Graphical abstract: Design of multivalent galactosyl carborane as a targeting specific agent for potential application to boron neutron capture therapy

Supplementary files

Article information

Article type
Communication
Submitted
21 Jul 2011
Accepted
07 Nov 2011
First published
23 Nov 2011

Chem. Commun., 2012,48, 612-614

Design of multivalent galactosyl carborane as a targeting specific agent for potential application to boron neutron capture therapy

C. Lai, Y. Lin, F. Chou, C. Liang, E. Lin, Y. Chuang and C. Lin, Chem. Commun., 2012, 48, 612 DOI: 10.1039/C1CC14447B

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