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The immunosuppressive side of PDT

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Abstract

Photodynamic therapy (PDT) is a promising novel therapeutic procedure for the management of a variety of solid tumors and many non-malignant diseases. PDT has been described as having a significant effect on the immune system, which may be either immunostimulatory or, in some circumstances, immunosuppressive. The immunosuppressive effects of PDT have nearly all been concerned with the suppression of the contact hypersensitivity reaction in mice. Here, we review the immunosuppressive aspects of PDT treatment and discuss some additional mechanisms that may be involved.

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Authors and Affiliations

  1. Wellman Center for Photomedicine, Massachusetts General Hospital, Blossom Street, BAR406, Boston, MA, USA

    Pawel Mroz & Michael R. Hamblin

  2. Department of Dermatology, Harvard Medical School, Boston, MA, 02114-2696, USA

    Pawel Mroz & Michael R. Hamblin

  3. Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, USA

    Michael R. Hamblin

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  1. Pawel Mroz
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Correspondence to Pawel Mroz.

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This article is published as part of a themed issue on immunological aspects and drug delivery technologies in PDT.

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Mroz, P., Hamblin, M.R. The immunosuppressive side of PDT. Photochem Photobiol Sci 10, 751–758 (2011). https://doi.org/10.1039/c0pp00345j

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