Issue 8, 2011
From the journal:

Organic & Biomolecular Chemistry

Synthesis, characterization and structures of 2-(3,5-dimethylpyrazol-1-yl)ethylseleno derivatives and their probable glutathione peroxidase (GPx) like activity†

Ananda S. Hodage,a   Prasad P. Phadnis,a   Amey Wadawale,a   K. I. Priyadarsinib  and  Vimal K. Jain*a  

* Corresponding authors

a Chemistry Division, Bhabha Atomic Research Centre, Trombay, India
E-mail: jainvk@barc.gov.in
Fax: +91-22-2550-5151
Tel: +91-22-2559-5095

b Radiation and Photochemistry Division, Bhabha Atomic Research Centre, Trombay, India

Abstract

A series of 2-(3,5-dimethylpyrazol-1-yl)ethylseleno derivatives has been synthesized. The glutathione peroxidase like catalytic activity of these compounds has been studied in a model system, in which reduction of hydrogen peroxide with dithiothreitol (DTTred), in the presence of an organoselenium compound was investigated by 1H NMR spectroscopy. All these compounds exhibit GPx like catalytic activities and the catalytic reaction proceeds through a selenoxide intermediate, identified by 77Se{1H} NMR spectroscopy.

Graphical abstract: Synthesis, characterization and structures of 2-(3,5-dimethylpyrazol-1-yl)ethylseleno derivatives and their probable glutathione peroxidase (GPx) like activity

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C0OB00807A
Article type
Paper
Submitted
01 Oct 2010
Accepted
14 Jan 2011
First published
03 Mar 2011

Org. Biomol. Chem., 2011,9, 2992-2998

Permissions

Request permissions

Synthesis, characterization and structures of 2-(3,5-dimethylpyrazol-1-yl)ethylseleno derivatives and their probable glutathione peroxidase (GPx) like activity

A. S. Hodage, P. P. Phadnis, A. Wadawale, K. I. Priyadarsini and V. K. Jain, Org. Biomol. Chem., 2011, 9, 2992 DOI: 10.1039/C0OB00807A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements