Polymer        nanoparticles with an embedded phosphorescent osmium(II) complex for cell imaging

Tianshe Yang; Ao Xia; Qian Liu; Mei Shi; Huazhou Wu; Liqin Xiong; Chunhui Huang; Fuyou Li

doi:10.1039/C0JM04235H

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Polymernanoparticles with an embedded phosphorescent osmium(ii) complex for cell imaging†

Tianshe Yang,^ab Ao Xia,^a Qian Liu,^a Mei Shi,*^a Huazhou Wu,^a Liqin Xiong,^a Chunhui Huang^a and Fuyou Li*^a

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* Corresponding authors

^a Department of Chemistry & Laboratory of Advanced Materials, Fudan University, Shanghai, P. R. China
E-mail: fyli@fudan.edu.cn, shimei@fudan.edu.cn
Fax: +86 21 55664621
Tel: +86 21 55664185

^b Jiangxi Key Laboratory of Organic Chemistry, Jiangxi Science & Technology Normal University, Nanchang, P. R. China

Abstract

Herein, we report the development of a simple and effective method for embedding a hydrophobic phosphorescent heavy-metal complex into hydrophilic nanoparticles by emulsion polymerization. An osmium(II) complex, [Os(bpy)₂(L^L)]²⁺(PF₆⁻)₂, has been synthesized, and its structure has been confirmed by single-crystal X-ray analysis. Phosphorescent polymer nanoparticles (PNPs) with the embedded Os(II) complex have been synthesized by emulsion polymerization. Investigation of its emission properties has shown that PNPs with the embedded Os(II) complex emits red phosphorescence in water, as well as the free Os(II) complex in organic solvents. Moreover, different from the very weak cellular uptake of the Os(II) complex, a good cellular uptake of the PNPs in cytoplasm has been observed, as well as a low cytotoxicity, making them promising candidates for use as living-cell imaging agents.

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Article information

DOI: https://doi.org/10.1039/C0JM04235H
Article type: Paper
Submitted: 04 Dec 2010
Accepted: 06 Jan 2011
First published: 11 Feb 2011

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J. Mater. Chem., 2011,21, 5360-5367

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Polymer nanoparticles with an embedded phosphorescent osmium(II) complex for cell imaging

T. Yang, A. Xia, Q. Liu, M. Shi, H. Wu, L. Xiong, C. Huang and F. Li, J. Mater. Chem., 2011, 21, 5360 DOI: 10.1039/C0JM04235H

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Journal of Materials Chemistry