Issue 6, 2011
From the journal:

Food & Function

Role of the COX-independent pathways in the ulcer-healing action of epigallocatechin gallate

Biplab Adhikary,†a   Sudhir K. Yadav,†a   Sandip K. Bandyopadhyaya  and  Subrata Chattopadhyay*b  

* Corresponding authors

a IPGME & R, 244B, Acharya Jagadish Chandra Bose Road, Kolkata, India

b Bio-Organic Division, Bhabha Atomic Research Centre, Mumbai, India
E-mail: schatt@barc.gov.in
Fax: +91-22-25505151
Tel: +91-22-25593703

Abstract

The modulation of the cyclooxygenase-independent pathway by the green tea-derived polyphenol, epigallocatechin gallate (EGCG) during its healing action against indomethacin (IND)-induced stomach ulceration in mice was investigated. On the 3rd day of its administration, IND (18 mg kg−1) induced maximum stomach ulceration which was associated with increased myeloperoxidase (MPO) activity (2.1-fold, p < 0.001), and inducible nitric oxide synthase (iNOS) expression (2.5-fold, p < 0.001), along with augmented levels of serum nitrite (1.3-fold, p < 0.001), selectins and cell adhesion molecules (CAMs), as well as reduced endothelial nitric oxide synthase (eNOS) expression (53%, p < 0.001). Treatment with EGCG (2 mg kg−1) and omeprazole (3 mg kg−1) for 3 days reversed these parameters, and provided excellent (76–77%) ulcer healing.

Graphical abstract: Role of the COX-independent pathways in the ulcer-healing action of epigallocatechin gallate

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Article information

DOI
https://doi.org/10.1039/C0FO00183J
Article type
Paper
Submitted
26 Dec 2010
Accepted
25 Apr 2011
First published
27 May 2011

Food Funct., 2011,2, 338-347

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Role of the COX-independent pathways in the ulcer-healing action of epigallocatechin gallate

B. Adhikary, S. K. Yadav, S. K. Bandyopadhyay and S. Chattopadhyay, Food Funct., 2011, 2, 338 DOI: 10.1039/C0FO00183J

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