Issue 24, 2010

Liposomes with conjugates of a calix[4]arene and a Gd-DOTA derivative on the outside surface; an efficient potential contrast agent for MRI

Abstract

Paramagnetic liposomes used as contrast agents in magnetic resonance imaging (MRI) often suffer from low efficacies because of slow water diffusion through the membrane. We present an approach to overcome this limitation by incorporation of a calix[4]arene based agent that expresses the chelates towards the bulk water.

Graphical abstract: Liposomes with conjugates of a calix[4]arene and a Gd-DOTA derivative on the outside surface; an efficient potential contrast agent for MRI

Supplementary files

Article information

Article type
Communication
Submitted
24 Feb 2010
Accepted
20 Apr 2010
First published
13 May 2010

Chem. Commun., 2010,46, 4399-4401

Liposomes with conjugates of a calix[4]arene and a Gd-DOTA derivative on the outside surface; an efficient potential contrast agent for MRI

D. T. Schühle, P. van Rijn, S. Laurent, L. Vander Elst, R. N. Muller, M. C. A. Stuart, J. Schatz and J. A. Peters, Chem. Commun., 2010, 46, 4399 DOI: 10.1039/C0CC00107D

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