Issue 16, 2010
From the journal:

Lab on a Chip

Rapid prototyping of microfluidic devices for integrating with FT-IRspectroscopic imaging

K. L. Andrew Chan,a   Xize Niu,b   Andrew J. de Mellob  and  Sergei G. Kazarian*a  

* Corresponding authors

a Department of Chemical Engineering, Imperial College London, United Kingdom
E-mail: s.kazarian@imperial.ac.uk
Tel: +44 (0)20 7594 5574

b Department of Chemistry, Imperial College London

Abstract

A versatile approach for the rapid prototyping of microfluidic devices suitable for use with FT-IR spectroscopic imaging is introduced. Device manufacture is based on the direct printing of paraffin onto the surface of an infrared transparent substrate, followed by encapsulation. Key features of this approach are low running costs, rapid production times, simplicity of design modifications and suitability for integration with FT-IR spectroscopic measurements. In the current experiments, the minimum width of channel walls was found to be ∼120 μm and ∼200 when a 25 μm and 12 μm spacer is used, respectively. Water and poly(ethylene glycol) are used as model fluids in a laminar flow regime, and are imaged in both transmission and attenuated total reflection (ATR) modes. It is established that adoption of transmission mode measurements yields superior sensitivity whilst the ATR mode is more suitable for quantitative analysis using strong spectral absorption bands. Results indicate that devices manufactured using this approach are suitable for use with in situ FT-IR spectroscopic imaging.

Graphical abstract: Rapid prototyping of microfluidic devices for integrating with FT-IR spectroscopic imaging

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Article information

DOI
https://doi.org/10.1039/C004246C
Article type
Technical Note
Submitted
15 Mar 2010
Accepted
28 Apr 2010
First published
07 Jun 2010

Lab Chip, 2010,10, 2170-2174

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Rapid prototyping of microfluidic devices for integrating with FT-IR spectroscopic imaging

K. L. A. Chan, X. Niu, A. J. de Mello and S. G. Kazarian, Lab Chip, 2010, 10, 2170 DOI: 10.1039/C004246C

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