Issue 13, 2010
From the journal:

Organic & Biomolecular Chemistry

CuBr-catalyzed selective oxidation of N-azomethine: highly efficient synthesis of methine-bridged bis-indole compounds†

Jianguo Yang,*a   Zhijing Wang,b   Fuyou Pan,a   Yongmin Lia  and  Weiliang Bao*b  

* Corresponding authors

a School of pharmaceutical and Chemical Engineering, Taizhou University, Taizhou 317000, China
E-mail: yjg@tzc.edu.cn

b Department of Chemistry, Xi Xi Campus, Zhejiang University, Hangzhou 310028, China
E-mail: wlbao@css.zju.edu.cn

Abstract

An efficient CuBr catalyzed cleavage of C–N bonds in the oxidative cross-dehydrogenative-coupling (CDC) of N-benzyl amines with indoles mediated by tert-butyl hydroperoxide (TBHP) was reported. A series of methine-bridged bis-indole derivatives were successfully synthesized under the optimized reaction conditions.

Graphical abstract: CuBr-catalyzed selective oxidation of N-azomethine: highly efficient synthesis of methine-bridged bis-indole compounds

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Article information

DOI
https://doi.org/10.1039/C004213G
Article type
Paper
Submitted
16 Mar 2010
Accepted
20 Apr 2010
First published
11 May 2010

Org. Biomol. Chem., 2010,8, 2975-2978

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CuBr-catalyzed selective oxidation of N-azomethine: highly efficient synthesis of methine-bridged bis-indole compounds

J. Yang, Z. Wang, F. Pan, Y. Li and W. Bao, Org. Biomol. Chem., 2010, 8, 2975 DOI: 10.1039/C004213G

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