Issue 16, 2010
From the journal:

Journal of Materials Chemistry

Surface deformation of goldnanorod-loaded poly(dl-lactide-co-glycolide) nanoparticles after near infrared irradiation: an active and controllable drug release system

Chih-Hang Chu,a   Yu-Chao Wang,b   Lin-Ai Tai,b   Li-Chen Wua  and  Chung-Shi Yang*ab  

* Corresponding authors

a Department of Applied Chemistry and Graduate Institute of Biomedicine and Biomedical Technology, National Chi-Nan University, Puli, Taiwan

b Center for Nanomedicine Research, National Health Research Institutes, 35 Keyand Rd. Zhunan, Mialoli, Taiwan, R. O. C.
E-mail: cyang@nhri.org.tw
Fax: +886-37-586447
Tel: +886-37-246-266 ext. 38100

Abstract

A novel drug release method for poly(DL-lactide-co-glycolide) (PLGA) nanoparticles is reported. NIR laser irradiation (808 ± 3 nm) on gold nanorods (GNRs) co-encapsulated in PLGA nanoparticles triggered surface protuberances (as studied by AFM) and induced rapid drug release. The NIR thus acts as a non-invasive external light source for active and controllable drug release from the PLGA/GNR composite nanoparticles. This type of drug delivery system may be of value in in vivo target delivery in the future.

Graphical abstract: Surface deformation of gold nanorod-loaded poly(dl-lactide-co-glycolide) nanoparticles after near infrared irradiation: an active and controllable drug release system

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Article information

DOI
https://doi.org/10.1039/B925651M
Article type
Paper
Submitted
04 Dec 2009
Accepted
08 Feb 2010
First published
08 Mar 2010

J. Mater. Chem., 2010,20, 3260-3264

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Surface deformation of gold nanorod-loaded poly(DL-lactide-co-glycolide) nanoparticles after near infrared irradiation: an active and controllable drug release system

C. Chu, Y. Wang, L. Tai, L. Wu and C. Yang, J. Mater. Chem., 2010, 20, 3260 DOI: 10.1039/B925651M

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