Issue 1, 2010
From the journal:

Molecular BioSystems

Incorporation of unnatural amino acids for synthetic biology

Natalya Voloshchuka  and  Jin Kim Montclareab  

a Department of Chemical and Biological Sciences, Polytechnic Institute of New York University, Brooklyn, USA

b Department of Biochemistry, SUNY-Downstate Medical Center, Brooklyn, USA
E-mail: jmontcla@poly.edu
Fax: +1 718-260-3676
Tel: +1 718-260-3679

Abstract

The challenge of synthetic biology lies in the construction of artificial cellular systems. This requires the development of modular “parts” that can be integrated into living systems to elicit an artificial, yet programmed, response or function. The development of methods to engineer proteins bearing unnatural amino acids (UAAs) provides essential components that may address this challenge. Here we review the emerging strategies for incorporating UAAs into proteins with the endgame of engineering artificial cells and organisms.

Graphical abstract: Incorporation of unnatural amino acids for synthetic biology

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Article information

DOI
https://doi.org/10.1039/B909200P
Article type
Review Article
Submitted
08 May 2009
Accepted
10 Aug 2009
First published
04 Sep 2009

Mol. BioSyst., 2010,6, 65-80

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Incorporation of unnatural amino acids for synthetic biology

N. Voloshchuk and J. K. Montclare, Mol. BioSyst., 2010, 6, 65 DOI: 10.1039/B909200P

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