Issue 2, 2009

Microwave-assisted synthesis in aqueous medium of new quinazoline derivatives as anticancer agent precursors

Abstract

Fast and eco-friendly microwave-irradiated reactions permitting the “green synthesis” of new 2-substituted quinazoline derivatives in aqueous medium via S-alkylation or SRN1 reaction from 2-chloromethyl-3-methylquinazolin-4(3H)-one derivatives with different benzenesulfinic acids and nitronate anions, are reported herein.

Graphical abstract: Microwave-assisted synthesis in aqueous medium of new quinazoline derivatives as anticancer agent precursors

Article information

Article type
Paper
Submitted
24 Sep 2008
Accepted
29 Oct 2008
First published
19 Nov 2008

Green Chem., 2009,11, 201-208

Microwave-assisted synthesis in aqueous medium of new quinazoline derivatives as anticancer agent precursors

Y. Kabri, A. Gellis and P. Vanelle, Green Chem., 2009, 11, 201 DOI: 10.1039/B816723K

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