Issue 43, 2008

Bioactive fragments synergically involved in the design of new generation Pt(ii) and Pd(ii)-based anticancer compounds

Abstract

New Pt(II) and Pd(II) complexes with the metal center coordinated to two different chelating ligands, tropolone (trop) and dihexadecyl-2,2′-bipyridine-4,4′-dicarboxylate bipyridine (bipy), [(bipy)M(trop)][CF3SO3], have been synthesized and their biological evaluation has been performed demonstrating a remarkable cytotoxic activity in vitro against the human prostate DU145 and hormone-sensitive LNCaP cells lines. Moreover, for the Pt(II) derivative, the molecular structure has been determined by single-crystal X-ray diffraction and computational analysis on the hydrolysis reaction mechanisms have been performed by density functional theory (DFT) calculations, in order to correlate molecular structure, biological activity and mechanism of action of this new class of complexes based on two different bioactive fragments.

Graphical abstract: Bioactive fragments synergically involved in the design of new generation Pt(ii) and Pd(ii)-based anticancer compounds

Supplementary files

Article information

Article type
Paper
Submitted
14 May 2008
Accepted
17 Jul 2008
First published
04 Sep 2008

Dalton Trans., 2008, 5897-5904

Bioactive fragments synergically involved in the design of new generation Pt(II) and Pd(II)-based anticancer compounds

D. Pucci, A. Bellusci, S. Bernardini, R. Bloise, A. Crispini, G. Federici, P. Liguori, M. F. Lucas, N. Russo and A. Valentini, Dalton Trans., 2008, 5897 DOI: 10.1039/B808093C

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