Issue 27, 2008
From the journal:

Chemical Communications

Novel neutral imidazole-lipophosphoramides for transfection assays†

Mathieu Mével,a   Cécile Neveu,a   Cristine Gonçalves,b   Jean-Jacques Yaouanc,*a   Chantal Pichon,b   Paul-Alain Jaffrèsa  and  Patrick Midoux*b  

* Corresponding authors

a CEMCA, UMR CNRS 6521, Université de Bretagne Occidentale, CNRS UMR 6521, 6 Avenue Le Gorgeu, 29238 Brest, France
E-mail: jean-jacques.yaouanc@univ-brest.fr
Fax: (+33) 298 017 001
Tel: (+33) 298 016 153

b Centre de Biophysique Moléculaire, CNRS UPR 4301 affiliated to Inserm and Université d’Orléans, Rue Charles Sadron, 45071 Orléans cedex 2, France
E-mail: patrick.midoux@cnrs-orleans.fr
Fax: (+33) 238 69 15 17
Tel: (+33) 238 25 55 95

Abstract

New helper lipids, possessing an imidazole polar head, have been synthesized and included in formulations for transfection assays; these new helper lipids can improve the transfection by a factor of up to 100 compared to the use of DOPE as co-lipid.

Graphical abstract: Novel neutral imidazole-lipophosphoramides for transfection assays

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Article information

DOI
https://doi.org/10.1039/B805226C
Article type
Communication
Submitted
27 Mar 2008
Accepted
07 May 2008
First published
16 Jun 2008

Chem. Commun., 2008, 3124-3126

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Novel neutral imidazole-lipophosphoramides for transfection assays

M. Mével, C. Neveu, C. Gonçalves, J. Yaouanc, C. Pichon, P. Jaffrès and P. Midoux, Chem. Commun., 2008, 3124 DOI: 10.1039/B805226C

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