Issue 9, 2008
From the journal:

Molecular BioSystems

Quorum sensing by 2-alkyl-4-quinolones in Pseudomonas aeruginosa and other bacterial species

Jean-Frédéric Duberna  and  Stephen P. Diggle*a  

* Corresponding authors

a Institute of Infection, Immunity & Inflammation, Centre of Biomolecular Sciences, University of Nottingham, Nottingham, United Kingdom
E-mail: steve.diggle@nottingham.ac.uk
Fax: +44 (0) 115 846-7951
Tel: +44 (0) 115 846-7954

Abstract

Pseudomonas aeruginosa produces the cell-to-cell signal molecule 2-heptyl-3-hydroxy-4-quinolone (The Pseudomonasquinolonesignal; PQS), which is integrated within a complicated quorum sensing signaling system. PQS belongs to the family of 2-alkyl-4-quinolones (AQs), which have been previously described for their antimicrobial activities. PQS is synthesized via the pqsABCDEoperon which is responsible for generating multiple AQs including 2-heptyl-4-quinolone (HHQ), the immediate PQS precursor. In addition, PQS signaling plays an important role in P. aeruginosapathogenesis because it regulates the production of diverse virulence factors including elastase, pyocyanin and LecA lectin in addition to affecting biofilm formation. Here, we summarize the most recent findings on the biosynthesis and regulation of PQS and other AQs including the discovery of AQs in other bacterial species.

Graphical abstract: Quorum sensing by 2-alkyl-4-quinolones in Pseudomonas aeruginosa and other bacterial species

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Article information

DOI
https://doi.org/10.1039/B803796P
Article type
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First published
30 Jun 2008

Mol. BioSyst., 2008,4, 882-888

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Quorum sensing by 2-alkyl-4-quinolones in Pseudomonas aeruginosa and other bacterial species

J. Dubern and S. P. Diggle, Mol. BioSyst., 2008, 4, 882 DOI: 10.1039/B803796P

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