Issue 10, 2008
From the journal:

New Journal of Chemistry

Structural characterisation of two pharmaceutically important steroids by solid-state NMR†

Abdullah Othman,ab   Robin K. Harris,*b   Paul Hodgkinson,b   Elizabeth A. Christophercb  and  Robert W. Lancasterb  

* Corresponding authors

a Hikma Parmaceuticals Ltd., PO Box 182400, Bayader Wadi Alseer, Amman, Jordan

b Department of Chemistry, University of Durham, South Road, Durham, UK
E-mail: r.k.harris@durham.ac.uk
Fax: +44-(0)191-384-4737
Tel: +44-(0)191-334-2021

c The Graduate School, University of Chester, Parkgate Road, Chester, UK

Abstract

Several crystal modifications of two steroids (androsterone and beclomethasone dipropionate) have been characterised by solid-state NMR methods, and the chemical shifts between the different forms compared. The gradual loss of water from androsterone hemihydrate has been monitored by XRPD. The crystal structures are discussed in relation to the NMR data. That of the beclomethasone dipropionate ethyl acetate solvate has been determined for the first time. It is found that there are clear channels containing the ethyl acetate molecules, which are apparently not incorporated by hydrogen bonding. Carbon-13 CP MAS spectra with long contact times and MAS proton spectra are used to show the mobility of ethyl acetate molecules in the BDP solvate. The second-order effect of chlorine on the 13C spectrum of beclomethasone dipropionate monohydrate has been explored by varying the applied magnetic field.

Graphical abstract: Structural characterisation of two pharmaceutically important steroids by solid-state NMR

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/B803586E
Article type
Paper
Submitted
03 Mar 2008
Accepted
21 Apr 2008
First published
14 Jul 2008

New J. Chem., 2008,32, 1796-1806

Permissions

Request permissions

Structural characterisation of two pharmaceutically important steroids by solid-state NMR

A. Othman, R. K. Harris, P. Hodgkinson, E. A. Christopher and R. W. Lancaster, New J. Chem., 2008, 32, 1796 DOI: 10.1039/B803586E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements