Volume 136, 2007

Sintering, crystallisation and biodegradation behaviour of Bioglass®-derived glass–ceramics

Abstract

Sintering and crystallisation phenomena in powders of a typical bioactive glass composition (45S5 Bioglass®) have been investigated in order to gain further understanding of the processes involved in the fabrication of Bioglass® based glass–ceramic scaffolds for tissue engineering applications. In situ experiments in an environmental scanning electron microscope with a heating stage were carried out to follow the morphology of Bioglass® particles during sintering and crystallisation. Optimal processing parameters for the manufacture of Bioglass® based glass–ceramic scaffolds by the foam-replica technique were determined. To assess the in vitro performance and bioreactivity of Bioglass®-derived glass–ceramic scaffolds, the biodegradation of samples in simulated body fluid (SBF) was investigated using various techniques, including SEM, TEM, XRD and EDX. The mechanism of interaction of the glass–ceramic surface with SBF was determined, which involves (i) preferential dissolution at glass/crystal interfaces, (ii) break-down of crystalline particles into very fine grains through preferential dissolution at crystal structural defects, and (iii) amorphisation of the crystalline structure by introduction of point defects produced during ion exchange. The present report thus offers for the first time a complete assessment of the processing parameters, microstructure, and in vitro performance of Bioglass® derived glass–ceramic scaffolds intended for bone tissue engineering.

Article information

Article type
Paper
Submitted
13 Nov 2006
Accepted
05 Feb 2007
First published
08 May 2007

Faraday Discuss., 2007,136, 27-44

Sintering, crystallisation and biodegradation behaviour of Bioglass®-derived glass–ceramics

A. R. Boccaccini, Q. Chen, L. Lefebvre, L. Gremillard and J. Chevalier, Faraday Discuss., 2007, 136, 27 DOI: 10.1039/B616539G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements