Issue 9, 2006
From the journal:

Journal of Materials Chemistry

Preliminary evaluation of new intrinsically radiopaque hydrogels for replacing the nucleus pulposus

Erik J. H. Boelen,*ab   Catharina S. J. van Hooy-Corstjens,a   Marion J. J. Gijbels,c   Sjoerd K. Bulstra,d   André van Ooij,d   Lodewijk W. van Rhijnd  and  Leo H. Kooleae  

* Corresponding authors

a Center for Biomaterials Research, University of Maastricht, UNS50, room 4.302, PO Box 616, 6200 MD Maastricht, The Netherlands
E-mail: e.boelen@bioch.unimaas.nl

b Dutch Polymer Institute (DPI), PO Box 902, 5600 AX Eindhoven, The Netherlands

c Department of Molecular Genetics and Department of Pathology, Cardiovascular Research Institute Maastricht, PO Box 616, 6200 MD Maastricht, The Netherlands

d Department of Orthopedic Surgery, Academic Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands

e Department of Biomedical Engineering, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands

Abstract

Treatment of early degenerative disc disease can, in some cases, be accomplished through implantation of a synthetic prosthesis for the nucleus pulposus. This treatment is attractive, since the annulus fibrosus—as well as the function of the disc—is preserved. This study reports on two new synthetic hydrogels which were specifically designed as fully radiopaque prosthetic nucleus biomaterials. Moreover, the new materials were engineered in such a way that they swell in situ (i.e., after implantation) to such an extent that they will fill the entire nucleus cavity. We describe: (i) assessment of the biocompatibility of the new biomaterials in an in vivo animal model, (ii) implantation of the new prosthesis in an ex vivo animal model (porcine spine), followed by (iii) assessment of the visibility of the entire nucleus prosthesis through both CT and MRI. The results further substantiate the idea that the concept of implantation of a prosthesis for the nucleus pulposus can benefit from contemporary insights and developments of novel synthetic biomaterials with intrinsic radiopacity.

Graphical abstract: Preliminary evaluation of new intrinsically radiopaque hydrogels for replacing the nucleus pulposus

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Article information

DOI
https://doi.org/10.1039/B515904K
Article type
Paper
Submitted
09 Nov 2005
Accepted
28 Nov 2005
First published
19 Dec 2005

J. Mater. Chem., 2006,16, 824-828

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Preliminary evaluation of new intrinsically radiopaque hydrogels for replacing the nucleus pulposus

E. J. H. Boelen, C. S. J. van Hooy-Corstjens, M. J. J. Gijbels, S. K. Bulstra, A. van Ooij, L. W. van Rhijn and L. H. Koole, J. Mater. Chem., 2006, 16, 824 DOI: 10.1039/B515904K

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