Issue 23, 2005
From the journal:

Physical Chemistry Chemical Physics

Energy dissipation in slipping biological pumps

Signe Kjelstrup,*a   J. Miguel Rubib  and  Dick Bedeauxa  

* Corresponding authors

a Department of Chemistry, Faculty of Natural Science and Technology, Norwegian University of Science and Technology, Trondheim, Norway
E-mail: signekj@phys.chem.ntnu.no

b Department de Fisica Fonamental, Universitat de Barcelona, Diagonal 647, Barcelona, Spain
E-mail: mrubi@ub.edu

Abstract

We describe active transport in slipping biological pumps, using mesoscopic nonequilibrium thermodynamics. The pump operation is characterised by its stochastic nature and energy dissipation. We show how heating as well as cooling effects can be associated with pump operation. We use as an example the well studied active transport of Ca2+ across a biological membrane by means of its ATPase, and use published data to find values for the transport coefficients of the pump under various conditions. Most of the transport coefficients of the pump, including those that relate ATP hydrolysis or synthesis to thermal effects, are estimated. This can give a quantitative description of thermogenesis. We show by calculation that all of these coupling coefficients are significant.

Graphical abstract: Energy dissipation in slipping biological pumps

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Article information

DOI
https://doi.org/10.1039/B511990A
Article type
Paper
Submitted
23 Aug 2005
Accepted
21 Sep 2005
First published
07 Oct 2005

Phys. Chem. Chem. Phys., 2005,7, 4009-4018

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Energy dissipation in slipping biological pumps

S. Kjelstrup, J. Miguel Rubi and D. Bedeaux, Phys. Chem. Chem. Phys., 2005, 7, 4009 DOI: 10.1039/B511990A

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