Issue 20, 2005
From the journal:

Organic & Biomolecular Chemistry

Synthesis of structures corresponding to the capsular polysaccharide of Neisseria meningitidis group A

Rikard Slättegård,a   Peter Teodorovic,a   Henok Hadgu Kinfe,b   Neil Ravenscroft,b   David W. Gammonb  and  Stefan Oscarson*a  

* Corresponding authors

a Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, Stockholm, Sweden
E-mail: s.oscarson@organ.su.se
Fax: +46 8154 908
Tel: +46 8162 480

b Department of Chemistry, University of Cape Town, Rondebosch, South Africa
E-mail: raveneil@science.uct.ac.za
Fax: +27 2168 974 99
Tel: +27 2165 043 54

Abstract

Four differently substituted trimers of the CPS repeating unit have been synthesised in order to investigate the dependence on oligosaccharide size, acetylation and mode of phosphorylation of glycoconjugate vaccines against Neisseria meningitidis group A. A spacer-containing starting monomer, a H-phosphonate elongating monomer and a 6-O-phosphorylated H-phosphonate cap monomer have been synthesised and coupled together to afford, after deprotection, the target trimer structures differing in their acetylation and phosphorylation substitution pattern.

Graphical abstract: Synthesis of structures corresponding to the capsular polysaccharide of Neisseria meningitidis group A

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Article information

DOI
https://doi.org/10.1039/B507898A
Article type
Paper
Submitted
06 Jun 2005
Accepted
23 Aug 2005
First published
13 Sep 2005

Org. Biomol. Chem., 2005,3, 3782-3787

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Synthesis of structures corresponding to the capsular polysaccharide of Neisseria meningitidis group A

R. Slättegård, P. Teodorovic, H. Hadgu Kinfe, N. Ravenscroft, D. W. Gammon and S. Oscarson, Org. Biomol. Chem., 2005, 3, 3782 DOI: 10.1039/B507898A

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